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Baseline metabolites were compared between the following groups: (1) Dogs with DCM eating NT diets (DCM-NT) + dogs with DCM eating T diets (DCM-T)] were compared to healthy control dogs eating NT diets (C-NT) + healthy control dogs eating T diets (C-T) and (2) Dogs eating NT diets (DCM-NT + C-NT) were compared to dogs eating T diets (DCM-T + C-T)

This suggests that further research, especially well-designed, long-term clinical trials, may be warranted

The clinical importance of these findings is in the recognition that DOX-induced autophagy functions as a critical pro-survival mechanism that emphasizes the therapeutic efficacy of chemotherapy across multiple cancers

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